Friedel-Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus


Prenylated indolocarbazoles have been reported neither from natural sources, nor by chemical synthetic approaches. In this Letter, we report a regiospecific prenylation of indolocarbazoles at the para-position of the indole N-atom by two recombinant enzymes from the dimethylallyltryptophan synthase (DMATS) superfamily, that is, 5-DMATS from Aspergillus clavatus and FgaPT2 from Aspergillus fumigatus.


Xia Yua, Aigang Yangb, Wenhan Linb, Shu-Ming Li


Tetrahedron Letters

Year, Volume, Page

2012, 53, 6861



Tag Element Regiochemistry Product Substrate Cofactor Enzyme
PTDBREC00237 C Regular FgaPT2
PTDBREC00238 C Regular 5-DMATS
PTDBREC00239 C Regular 5-DMATS
PTDBREC00240 C Regular 5-DMATS
PTDBREC00241 C Regular FgaPT2
PTDBREC00242 C Regular 5-DMATS
PTDBREC00243 C Regular FgaPT2
PTDBREC00244 C Regular 5-DMATS