Title
Friedel-Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus
Abstract
Prenylated indolocarbazoles have been reported neither from natural sources, nor by chemical synthetic approaches. In this Letter, we report a regiospecific prenylation of indolocarbazoles at the para-position of the indole N-atom by two recombinant enzymes from the dimethylallyltryptophan synthase (DMATS) superfamily, that is, 5-DMATS from Aspergillus clavatus and FgaPT2 from Aspergillus fumigatus.
Authors
Xia Yua, Aigang Yangb, Wenhan Linb, Shu-Ming Li
Journal
Tetrahedron Letters
Year, Volume, Page
2012, 53, 6861
| Tag | Element | Regiochemistry | Product | Substrate | Cofactor | Enzyme |
|---|---|---|---|---|---|---|
| PTDBREC00237 | C | Regular |  |
 |
 |
FgaPT2 |
| PTDBREC00238 | C | Regular | |
|
|
5-DMATS |
| PTDBREC00239 | C | Regular |  |
|
|
5-DMATS |
| PTDBREC00240 | C | Regular |  |
|
|
5-DMATS |
| PTDBREC00241 | C | Regular |  |
 |
|
FgaPT2 |
| PTDBREC00242 | C | Regular | |
|
|
5-DMATS |
| PTDBREC00243 | C | Regular |  |
 |
|
FgaPT2 |
| PTDBREC00244 | C | Regular | |
|
|
5-DMATS |